In the table below you can see the SeRenDIP-CE Conformational Epitope prediction example P0DTD3 — Name: SARS-CoV-2 Uncharacterized protein 14 — UniProtKB: Y14_SARS2
. The table
contains sequence position, prediction scores and classification based on the default cut-off of 0.5 (above is predicted interaction).
Qingzhen Hou1, Reza Haydarlou, Bas Stringer, Katharina Waury, Henriette Capel, Sanne Abeln, Jaap Heringa, K. Anton Feenstra
SeRenDIP-CE: Sequence-based Interface Prediction for Conformational Epitopes
Bioinformatics advance 11 May 2021, doi: 10.1093/bioinformatics/btab3211Department of Biostatistics, School of Public Health &
National institute of health data science of China; Shandong 250002, P. R. China
Qingzhen Hou1, Paul De Geest, Christian Griffioen, Sanne Abeln,
Jaap Heringa, K. Anton Feenstra.
SeRenDIP: remastered alignment profiles for fast
and accurate predictions of PPI interface positions.Bioinformatics 35, pp 4794–4796, 2019, doi: 10.1093/bioinformatics/btz428 13BIO-BioInfo – BioModeling, BioInformatics & BioProcesses, Université Libre de Bruxelles
Qingzhen Hou, Paul De Geest, Wim F. Vranken, Jaap Heringa and K. Anton Feenstra Seeing the Trees through the Forest:
Sequence-based Homo- and Heteromeric
Protein-protein Interaction sites prediction using
Random Forest. Bioinformatics, 2017, doi: 10.1093/bioinformatics/btx005
Color better than threshold:
Sequence
Models
Epitope Prediction
Pos
AA
Model 1
Model 2
Model 3
Model 4
Model 5
Average
Pred
Std. Dev.
Z-score
x of 65 rows match filter(s)
5
C
0.638
0.642
0.588
0.628
0.562
0.612
I
0.0350
0.1759
6
Y
0.694
0.550
0.594
0.658
0.586
0.616
I
0.0583
0.2519
7
N
0.696
0.640
0.576
0.738
0.576
0.645
I
0.0721
0.7076
8
F
0.708
0.608
0.620
0.722
0.644
0.660
I
0.0517
0.9482
9
L
0.674
0.638
0.642
0.672
0.614
0.648
I
0.0252
0.7520
10
K
0.648
0.616
0.620
0.716
0.614
0.643
I
0.0432
0.6697
11
E
0.692
0.550
0.672
0.742
0.600
0.651
I
0.0762
0.8026
12
Q
0.626
0.542
0.684
0.734
0.622
0.642
I
0.0723
0.6507
13
H
0.680
0.586
0.702
0.722
0.664
0.671
I
0.0522
1.1128
14
C
0.672
0.634
0.580
0.690
0.618
0.639
I
0.0437
0.6064
15
Q
0.706
0.630
0.674
0.738
0.634
0.676
I
0.0464
1.2014
16
K
0.802
0.684
0.728
0.830
0.722
0.753
I
0.0606
2.4169
17
A
0.702
0.626
0.662
0.706
0.670
0.673
I
0.0327
1.1508
18
S
0.756
0.614
0.684
0.762
0.684
0.700
I
0.0610
1.5749
19
T
0.792
0.670
0.674
0.772
0.630
0.708
I
0.0704
1.6952
20
Q
0.782
0.612
0.678
0.746
0.612
0.686
I
0.0772
1.3534
21
K
0.746
0.658
0.708
0.796
0.684
0.718
I
0.0541
1.8661
22
G
0.694
0.676
0.628
0.696
0.642
0.667
I
0.0308
1.0558
23
A
0.702
0.616
0.610
0.654
0.606
0.638
I
0.0408
0.5874
24
E
0.728
0.636
0.630
0.734
0.608
0.667
I
0.0592
1.0558
25
A
0.648
0.656
0.614
0.724
0.664
0.661
I
0.0399
0.9609
26
A
0.642
0.652
0.638
0.694
0.620
0.649
I
0.0276
0.7710
27
V
0.642
0.602
0.594
0.696
0.566
0.620
I
0.0504
0.3088
28
K
0.648
0.642
0.674
0.650
0.614
0.646
I
0.0215
0.7140
29
P
0.640
0.664
0.632
0.704
0.700
0.668
I
0.0332
1.0685
30
L
0.558
0.626
0.604
0.634
0.618
0.608
I
0.0301
0.1189
31
L
0.552
0.610
0.582
0.630
0.606
0.596
I
0.0299
-0.0710
32
V
0.554
0.594
0.574
0.638
0.586
0.589
I
0.0312
-0.1786
33
P
0.526
0.624
0.518
0.594
0.626
0.578
I
0.0524
-0.3622
34
H
0.562
0.654
0.594
0.634
0.626
0.614
I
0.0362
0.2139
35
H
0.584
0.642
0.610
0.656
0.680
0.634
I
0.0379
0.5367
36
V
0.554
0.648
0.608
0.540
0.634
0.597
I
0.0479
-0.0583
37
V
0.534
0.586
0.634
0.584
0.668
0.601
I
0.0514
0.0113
38
A
0.578
0.614
0.624
0.578
0.642
0.607
I
0.0285
0.1063
39
T
0.548
0.602
0.650
0.580
0.662
0.608
I
0.0477
0.1252
40
V
0.556
0.604
0.644
0.588
0.652
0.609
I
0.0398
0.1316
41
Q
0.576
0.602
0.596
0.618
0.662
0.611
I
0.0323
0.1632
42
E
0.562
0.630
0.592
0.648
0.686
0.624
I
0.0483
0.3658
43
I
0.518
0.580
0.608
0.540
0.682
0.586
I
0.0642
-0.2356
44
Q
0.528
0.664
0.618
0.596
0.636
0.608
I
0.0514
0.1252
45
L
0.522
0.700
0.622
0.556
0.688
0.618
I
0.0786
0.2708
46
Q
0.460
0.666
0.626
0.574
0.632
0.592
I
0.0806
-0.1406
47
A
0.520
0.610
0.642
0.506
0.612
0.578
I
0.0609
-0.3559
48
A
0.486
0.612
0.568
0.572
0.616
0.571
I
0.0523
-0.4698
49
V
0.438
0.588
0.580
0.540
0.650
0.559
I
0.0784
-0.6534
50
G
0.444
0.554
0.608
0.524
0.574
0.541
I
0.0621
-0.9446
51
E
0.494
0.618
0.582
0.618
0.602
0.583
I
0.0518
-0.2799
52
L
0.512
0.542
0.544
0.538
0.628
0.553
I
0.0440
-0.7547
53
L
0.464
0.594
0.582
0.550
0.604
0.559
I
0.0568
-0.6597
54
L
0.476
0.548
0.520
0.472
0.572
0.518
I
0.0439
-1.3118
55
L
0.412
0.558
0.524
0.486
0.598
0.516
I
0.0712
-1.3434
56
E
0.400
0.536
0.502
0.490
0.546
0.495
NI
0.0578
-1.6726
57
W
0.418
0.554
0.478
0.452
0.552
0.491
NI
0.0606
-1.7359
58
L
0.384
0.532
0.496
0.502
0.530
0.489
NI
0.0608
-1.7676
59
A
0.444
0.504
0.536
0.440
0.522
0.489
NI
0.0446
-1.7612
60
M
0.428
0.572
0.518
0.488
0.556
0.512
I
0.0575
-1.3941
61
A
0.500
0.560
0.536
0.492
0.516
0.521
I
0.0276
-1.2611
62
V
0.516
0.516
0.510
0.496
0.552
0.518
I
0.0207
-1.3054
63
M
0.568
0.534
0.532
0.484
0.558
0.535
I
0.0325
-1.0332
64
L
0.570
0.526
0.474
0.530
0.530
0.526
I
0.0342
-1.1788
65
L
0.554
0.506
0.522
0.606
0.598
0.557
I
0.0445
-0.6851
66
L
0.540
0.552
0.478
0.496
0.538
0.521
I
0.0320
-1.2611
67
L
0.532
0.438
0.494
0.520
0.572
0.511
I
0.0497
-1.4131
68
C
0.532
0.492
0.512
0.516
0.554
0.521
I
0.0232
-1.2548
69
C
0.560
0.536
0.488
0.560
0.516
0.532
I
0.0307
-1.0839
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