In the table below you can see the SeRenDIP-CE Conformational Epitope prediction example P0DTC6 — Name: SARS-CoV-2 Non-structural protein 6 — UniProtKB: NS6_SARS2
. The table
contains sequence position, prediction scores and classification based on the default cut-off of 0.5 (above is predicted interaction).
Qingzhen Hou1, Reza Haydarlou, Bas Stringer, Katharina Waury, Henriette Capel, Sanne Abeln, Jaap Heringa, K. Anton Feenstra
SeRenDIP-CE: Sequence-based Interface Prediction for Conformational Epitopes
Bioinformatics advance 11 May 2021, doi: 10.1093/bioinformatics/btab3211Department of Biostatistics, School of Public Health &
National institute of health data science of China; Shandong 250002, P. R. China
Qingzhen Hou1, Paul De Geest, Christian Griffioen, Sanne Abeln,
Jaap Heringa, K. Anton Feenstra.
SeRenDIP: remastered alignment profiles for fast
and accurate predictions of PPI interface positions.Bioinformatics 35, pp 4794–4796, 2019, doi: 10.1093/bioinformatics/btz428 13BIO-BioInfo – BioModeling, BioInformatics & BioProcesses, Université Libre de Bruxelles
Qingzhen Hou, Paul De Geest, Wim F. Vranken, Jaap Heringa and K. Anton Feenstra Seeing the Trees through the Forest:
Sequence-based Homo- and Heteromeric
Protein-protein Interaction sites prediction using
Random Forest. Bioinformatics, 2017, doi: 10.1093/bioinformatics/btx005
Color better than threshold:
Sequence
Models
Epitope Prediction
Pos
AA
Model 1
Model 2
Model 3
Model 4
Model 5
Average
Pred
Std. Dev.
Z-score
x of 53 rows match filter(s)
5
V
0.570
0.656
0.632
0.600
0.636
0.619
I
0.0339
0.6746
6
D
0.570
0.748
0.700
0.722
0.700
0.688
I
0.0689
1.5900
7
F
0.534
0.728
0.622
0.678
0.690
0.650
I
0.0753
1.0926
8
Q
0.518
0.736
0.676
0.694
0.694
0.664
I
0.0843
1.2672
9
V
0.466
0.586
0.598
0.566
0.614
0.566
I
0.0586
-0.0239
10
T
0.474
0.612
0.584
0.596
0.668
0.587
I
0.0708
0.2513
11
I
0.444
0.630
0.610
0.570
0.654
0.582
I
0.0829
0.1825
12
A
0.440
0.592
0.510
0.470
0.606
0.524
I
0.0733
-0.5847
13
E
0.400
0.638
0.508
0.514
0.630
0.538
I
0.0987
-0.3942
14
I
0.372
0.574
0.392
0.424
0.496
0.452
NI
0.0831
-1.5372
15
L
0.336
0.548
0.456
0.424
0.586
0.470
NI
0.0998
-1.2938
16
L
0.356
0.532
0.414
0.402
0.520
0.445
NI
0.0773
-1.6271
17
I
0.408
0.602
0.476
0.450
0.554
0.498
NI
0.0788
-0.9234
18
I
0.396
0.538
0.506
0.458
0.600
0.500
NI
0.0776
-0.9022
19
M
0.426
0.468
0.478
0.410
0.586
0.474
NI
0.0689
-1.2461
20
R
0.422
0.578
0.474
0.534
0.520
0.506
I
0.0597
-0.8228
21
T
0.454
0.494
0.384
0.416
0.552
0.460
NI
0.0659
-1.4260
22
F
0.468
0.520
0.452
0.466
0.572
0.496
NI
0.0499
-0.9551
23
K
0.436
0.588
0.466
0.530
0.594
0.523
I
0.0709
-0.5953
24
V
0.466
0.534
0.470
0.436
0.560
0.493
NI
0.0517
-0.9869
25
S
0.460
0.550
0.478
0.478
0.594
0.512
I
0.0574
-0.7382
26
I
0.458
0.576
0.502
0.496
0.608
0.528
I
0.0619
-0.5265
27
W
0.450
0.600
0.478
0.432
0.540
0.500
NI
0.0693
-0.8969
28
N
0.440
0.592
0.540
0.512
0.568
0.530
I
0.0588
-0.4948
29
L
0.440
0.576
0.448
0.434
0.546
0.489
NI
0.0669
-1.0451
30
D
0.428
0.636
0.474
0.526
0.560
0.525
I
0.0799
-0.5689
31
Y
0.446
0.560
0.440
0.444
0.552
0.488
NI
0.0618
-1.0504
32
I
0.436
0.562
0.464
0.510
0.606
0.516
I
0.0696
-0.6906
33
I
0.396
0.558
0.504
0.466
0.590
0.503
I
0.0765
-0.8599
34
N
0.466
0.538
0.440
0.528
0.514
0.497
NI
0.0423
-0.9340
35
L
0.480
0.562
0.488
0.518
0.446
0.499
NI
0.0436
-0.9128
36
I
0.524
0.616
0.564
0.592
0.596
0.578
I
0.0356
0.1402
37
I
0.452
0.490
0.510
0.548
0.576
0.515
I
0.0486
-0.6958
38
K
0.574
0.592
0.544
0.546
0.622
0.576
I
0.0328
0.1031
39
N
0.634
0.596
0.556
0.604
0.624
0.603
I
0.0303
0.4629
40
L
0.586
0.534
0.564
0.630
0.644
0.592
I
0.0456
0.3148
41
S
0.540
0.558
0.572
0.550
0.620
0.568
I
0.0313
0.0026
42
K
0.604
0.676
0.596
0.602
0.634
0.622
I
0.0334
0.7222
43
S
0.562
0.626
0.628
0.660
0.622
0.620
I
0.0356
0.6852
44
L
0.598
0.614
0.616
0.652
0.574
0.611
I
0.0285
0.5688
45
T
0.614
0.624
0.594
0.652
0.576
0.612
I
0.0290
0.5846
46
E
0.712
0.680
0.616
0.742
0.644
0.679
I
0.0506
1.4683
47
N
0.668
0.668
0.608
0.720
0.634
0.660
I
0.0422
1.2143
48
K
0.658
0.636
0.724
0.726
0.720
0.693
I
0.0426
1.6535
49
Y
0.652
0.620
0.652
0.638
0.634
0.639
I
0.0135
0.9444
50
S
0.690
0.634
0.626
0.712
0.642
0.661
I
0.0379
1.2302
51
Q
0.754
0.706
0.682
0.724
0.708
0.715
I
0.0266
1.9445
52
L
0.656
0.674
0.624
0.734
0.646
0.667
I
0.0417
1.3095
53
D
0.734
0.724
0.680
0.730
0.690
0.712
I
0.0248
1.9022
54
E
0.720
0.652
0.606
0.684
0.674
0.667
I
0.0421
1.3148
55
E
0.640
0.620
0.578
0.684
0.600
0.624
I
0.0405
0.7487
56
Q
0.662
0.608
0.596
0.684
0.586
0.627
I
0.0432
0.7857
57
P
0.534
0.578
0.518
0.542
0.506
0.536
I
0.0275
-0.4260
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