In the table below you can see the SeRenDIP PPI interface prediction example P0DTC3 — Name: SARS-CoV-2 Protein 3a — UniProtKB: AP3A_SARS2
. The table
contains sequence position, prediction scores and classification based on the default cut-off of 0.5 (above is predicted interaction).
Qingzhen Hou1, Reza Haydarlou, Bas Stringer, Katharina Waury, Henriette Capel, Sanne Abeln, Jaap Heringa, K. Anton Feenstra
SeRenDIP-CE: Sequence-based Interface Prediction for Conformational Epitopes
Bioinformatics advance 11 May 2021, doi: 10.1093/bioinformatics/btab3211Department of Biostatistics, School of Public Health &
National institute of health data science of China; Shandong 250002, P. R. China
Qingzhen Hou1, Paul De Geest, Christian Griffioen, Sanne Abeln,
Jaap Heringa, K. Anton Feenstra.
SeRenDIP: remastered alignment profiles for fast
and accurate predictions of PPI interface positions.Bioinformatics 35, pp 4794–4796, 2019, doi: 10.1093/bioinformatics/btz428 13BIO-BioInfo – BioModeling, BioInformatics & BioProcesses, Université Libre de Bruxelles
Qingzhen Hou, Paul De Geest, Wim F. Vranken, Jaap Heringa and K. Anton Feenstra Seeing the Trees through the Forest:
Sequence-based Homo- and Heteromeric
Protein-protein Interaction sites prediction using
Random Forest. Bioinformatics, 2017, doi: 10.1093/bioinformatics/btx005
Color better than threshold:
Sequence
Combined Prediction
Pos
AA
Model
Pred
x of 267 rows match filter(s)
5
M
0.516
I
6
R
0.564
I
7
I
0.468
NI
8
F
0.542
I
9
T
0.530
I
10
I
0.540
I
11
G
0.482
NI
12
T
0.518
I
13
V
0.530
I
14
T
0.518
I
15
L
0.496
NI
16
K
0.518
I
17
Q
0.546
I
18
G
0.518
I
19
E
0.492
NI
20
I
0.496
NI
21
K
0.458
NI
22
D
0.502
I
23
A
0.496
NI
24
T
0.450
NI
25
P
0.466
NI
26
S
0.446
NI
27
D
0.514
I
28
F
0.516
I
29
V
0.494
NI
30
R
0.556
I
31
A
0.528
I
32
T
0.566
I
33
A
0.558
I
34
T
0.566
I
35
I
0.588
I
36
P
0.586
I
37
I
0.516
I
38
Q
0.540
I
39
A
0.554
I
40
S
0.512
I
41
L
0.528
I
42
P
0.584
I
43
F
0.564
I
44
G
0.494
NI
45
W
0.512
I
46
L
0.508
I
47
I
0.494
NI
48
V
0.442
NI
49
G
0.398
NI
50
V
0.390
NI
51
A
0.424
NI
52
L
0.402
NI
53
L
0.426
NI
54
A
0.446
NI
55
V
0.444
NI
56
F
0.426
NI
57
Q
0.530
I
58
S
0.568
I
59
A
0.520
I
60
S
0.550
I
61
K
0.576
I
62
I
0.496
NI
63
I
0.528
I
64
T
0.552
I
65
L
0.520
I
66
K
0.498
NI
67
K
0.580
I
68
R
0.492
NI
69
W
0.512
I
70
Q
0.552
I
71
L
0.516
I
72
A
0.452
NI
73
L
0.482
NI
74
S
0.544
I
75
K
0.510
I
76
G
0.472
NI
77
V
0.480
NI
78
H
0.488
NI
79
F
0.478
NI
80
V
0.482
NI
81
C
0.416
NI
82
N
0.390
NI
83
L
0.376
NI
84
L
0.380
NI
85
L
0.378
NI
86
L
0.374
NI
87
F
0.372
NI
88
V
0.368
NI
89
T
0.374
NI
90
V
0.436
NI
91
Y
0.346
NI
92
S
0.378
NI
93
H
0.380
NI
94
L
0.432
NI
95
L
0.432
NI
96
L
0.432
NI
97
V
0.418
NI
98
A
0.422
NI
99
A
0.452
NI
100
G
0.460
NI
101
L
0.490
NI
102
E
0.488
NI
103
A
0.514
I
104
P
0.436
NI
105
F
0.472
NI
106
L
0.464
NI
107
Y
0.374
NI
108
L
0.386
NI
109
Y
0.376
NI
110
A
0.386
NI
111
L
0.382
NI
112
V
0.408
NI
113
Y
0.378
NI
114
F
0.398
NI
115
L
0.404
NI
116
Q
0.400
NI
117
S
0.452
NI
118
I
0.380
NI
119
N
0.430
NI
120
F
0.408
NI
121
V
0.436
NI
122
R
0.370
NI
123
I
0.438
NI
124
I
0.510
I
125
M
0.502
I
126
R
0.414
NI
127
L
0.484
NI
128
W
0.434
NI
129
L
0.454
NI
130
C
0.442
NI
131
W
0.474
NI
132
K
0.550
I
133
C
0.466
NI
134
R
0.474
NI
135
S
0.520
I
136
K
0.526
I
137
N
0.514
I
138
P
0.500
NI
139
L
0.514
I
140
L
0.470
NI
141
Y
0.552
I
142
D
0.510
I
143
A
0.512
I
144
N
0.542
I
145
Y
0.498
NI
146
F
0.478
NI
147
L
0.416
NI
148
C
0.388
NI
149
W
0.468
NI
150
H
0.430
NI
151
T
0.462
NI
152
N
0.472
NI
153
C
0.506
I
154
Y
0.472
NI
155
D
0.526
I
156
Y
0.504
I
157
C
0.494
NI
158
I
0.526
I
159
P
0.560
I
160
Y
0.546
I
161
N
0.496
NI
162
S
0.496
NI
163
V
0.516
I
164
T
0.504
I
165
S
0.526
I
166
S
0.550
I
167
I
0.488
NI
168
V
0.484
NI
169
I
0.478
NI
170
T
0.476
NI
171
S
0.526
I
172
G
0.518
I
173
D
0.492
NI
174
G
0.544
I
175
T
0.502
I
176
T
0.482
NI
177
S
0.500
NI
178
P
0.476
NI
179
I
0.508
I
180
S
0.510
I
181
E
0.482
NI
182
H
0.512
I
183
D
0.492
NI
184
Y
0.540
I
185
Q
0.544
I
186
I
0.500
NI
187
G
0.502
I
188
G
0.506
I
189
Y
0.468
NI
190
T
0.520
I
191
E
0.468
NI
192
K
0.476
NI
193
W
0.492
NI
194
E
0.472
NI
195
S
0.502
I
196
G
0.468
NI
197
V
0.506
I
198
K
0.510
I
199
D
0.470
NI
200
C
0.532
I
201
V
0.468
NI
202
V
0.482
NI
203
L
0.468
NI
204
H
0.488
NI
205
S
0.500
NI
206
Y
0.490
NI
207
F
0.502
I
208
T
0.500
NI
209
S
0.528
I
210
D
0.544
I
211
Y
0.550
I
212
Y
0.506
I
213
Q
0.568
I
214
L
0.538
I
215
Y
0.534
I
216
S
0.548
I
217
T
0.508
I
218
Q
0.502
I
219
L
0.494
NI
220
S
0.520
I
221
T
0.516
I
222
D
0.480
NI
223
T
0.482
NI
224
G
0.496
NI
225
V
0.492
NI
226
E
0.526
I
227
H
0.560
I
228
V
0.518
I
229
T
0.540
I
230
F
0.532
I
231
F
0.480
NI
232
I
0.434
NI
233
Y
0.446
NI
234
N
0.452
NI
235
K
0.506
I
236
I
0.536
I
237
V
0.558
I
238
D
0.502
I
239
E
0.486
NI
240
P
0.452
NI
241
E
0.476
NI
242
E
0.458
NI
243
H
0.534
I
244
V
0.480
NI
245
Q
0.478
NI
246
I
0.428
NI
247
H
0.480
NI
248
T
0.460
NI
249
I
0.524
I
250
D
0.572
I
251
G
0.582
I
252
S
0.530
I
253
S
0.564
I
254
G
0.568
I
255
V
0.562
I
256
V
0.562
I
257
N
0.580
I
258
P
0.544
I
259
V
0.568
I
260
M
0.542
I
261
E
0.524
I
262
P
0.582
I
263
I
0.534
I
264
Y
0.550
I
265
D
0.532
I
266
E
0.550
I
267
P
0.566
I
268
T
0.554
I
269
T
0.542
I
270
T
0.562
I
271
T
0.556
I
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