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Sequence Harmony |
Please do not link this web address!
For stable links, please refer to www.ibi.vu.nl/programs/ or www.ibi.vu.nl/programs/seqharmwww/.
The Sequence Harmony server has been retired. Please use its successor multi-Harmony.
Sequence Harmony is an entropy-based method, which accurately detects subfamily specific functional sites from a multiple sequence alignment. The algorithm implements a new formula, able to score compositional differences between subfamilies in a simple manner on an intuitive scale.
Information on the Input format
More on Method Background
If you use our method, please cite:
Feenstra KA, Pirovano WA, Krab K and Heringa J. Sequence Harmony: Detecting Functional Specificity from Alignments. Nucl. Acids Res., 2007, Vol. 35, W495-W498.
Pirovano WA1, Feenstra KA1 and Heringa J. Sequence Comparison by Sequence Harmony Identifies Subtype Specific Functional Sites. Nucl. Acids Res., 2006, Vol. 34, No. 22 6540-6548.
1 joint first authors
Showcases:
The Sequence Harmony web server developed and Copyright (c) by K. Anton Feenstra and Walter Pirovano
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