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Distribution of hits
The graph below show the distribution of the hits over your query.
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PRC hit table
Download: PRC scores file and
PRC alignments file .
Results of search against Pfam 23.0 - July 2008 (10340 profiles):
hit (hmm2) description simple reverse E-value
SprT-like Uncharacterized conserved protein (SprT-like): This... >> 201.9 193.5 3.7e-98
DUF335 Putative metallopeptidase (SprT family): This famil... >> 44.2 34.4 9.7e-15
Peptidase_M76 Peptidase M76 family: This is a family of metallopr... >> 23.4 15.1 0.00013
WLM WLM domain: This is a predicted metallopeptidase do... >> 21.0 12.4 0.0033
DUF2265 Predicted aminopeptidase (DUF2265): Members of this... >> 18.8 12.0 0.0052
Peptidase_M48 Peptidase family M48 17.2 11.2 0.015
BSP Plant Basic Secretory Protein: These basic secretor... >> 17.2 10.8 0.023
Peptidase_M56 BlaR1 peptidase M56: Production of beta-Lactamase a... >> 17.0 10.0 0.059
Mcm10 Mcm10 replication factor: Mcm10 is a eukaryotic DNA... >> 19.1 9.1 0.19
Peptidase_M30 Peptidase M30: This family contains the metallopept... >> 17.8 8.1 0.62
PipA PipA protein: This family consists of several Salmo... >> 15.7 7.7 0.97
Alignments >Hit (#1): SprT-like
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Download Uncharacterized conserved protein (SprT-like) This family represents approximately 160 residues of a group of
proteins conserved from fungi to humans. Some members are
annotated as SprT-like metallo-proteases but this could not be
confirmed. The function is not known.
Length=192
Score = 193.5, Expect = 3.7e-98
Match = 187/197 (95%), Insert = 2/197 (1%), Delete = 8/197 (4%)
Query 1 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM~IMMM~~~MMDD 55
Sbjct 1 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMDMMMMDDDMM~~ 58
Query 56 DMMMMDMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM 115
Sbjct 59 ~MMIM~MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM 115
Query 116 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM 175
Sbjct 116 MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM 175
Query 176 MMMMMMMMMMMMMMMMM 192
Sbjct 176 MMMMMMMMMMMMMMMMM 192
Aligned alignments:
A0BYE9_PAR 16 P-PDIFELFQFYNQYFFEGIL-.--VT---CTVKW...ST-RMTLCAgkqfflskGTCKY 63
Consensus 1 PLPDLLELFHRFNRQVFDGKLQkLAEGQPLVEVRWatdSKGRMTRTAgkqfflsiGICRY 60
++++++++++++++++++++++ ++++++++++++ +++++++++ +++++
Consensus 1 PLPDLLELFHRFNRQVFDGKLQkLAEGQPLVEVRWatdSKGRMTRTAgkqfflsiGICRY 60
A0BYE9_PAR 16 P-PDIFELFQFYNQYFFEGIL-.--VT---CTVKW...ST-RMTLCAgkqfflskGTCKY 63
A0BYE9_PAR 64 :.~-E-::::::::::::::~~:::~--..............--...--GQK.-SC.... 69
Consensus 61 :g~AKR::::::::::::::~~:::~EIiekkgpagtagscpAAshnRGGGGkKGCpeyl 98
+++ ++ ++ + ++
Consensus 61 gAKREIiekkgpagtagscpAAshnRGG::::::::::::::~~:::~GGkK:~GCpeyl 98
A0BYE9_PAR 64 .-E---..............--...--G::::::::::::::~~:::~QK.-:~SC.... 69
A0BYE9_PAR 70 ..........TIT..LSEPLLKFR..SNDELKS......................TLLHE 93
Consensus 99 psqaayrhhaEIRieLSEPLLKLRnyPRKDLVEvssvdgralrtassflgssvpqTLLHE 158
+++ +++++++++ +++++++ +++++
Consensus 99 psqaayrhhaEIRieLSEPLLKLRnyPRKDLVEvssvdgralrtassflgssvpqTLLHE 158
A0BYE9_PAR 70 ..........TIT..LSEPLLKFR..SNDELKS......................TLLHE 93
A0BYE9_PAR 94 MIHAYLFITk...pSEAFINE-.GHGPAFLEKMNFINQVT.--------GLELSVYHQFH 139
Consensus 159 MIHAYLFLIcgpagERLDDRERdGHGPNFKKWMRRINKAQiKDHPRYPEGFNITVYHSFH 218
+++++++++ ++++++++ +++++++++++++++++ +++++++++++++++++++
Consensus 159 MIHAYLFLIcgpagERLDDRERdGHGPNFKKWMRRINKAQiKDHPRYPEGFNITVYHSFH 218
A0BYE9_PAR 94 MIHAYLFITk...pSEAFINE-.GHGPAFLEKMNFINQVT.--------GLELSVYHQFH 139
A0BYE9_PAR 140 DE..VDRCRNHIWRCNGR-CQQK........PPFFGYVKRAI..NRPPGKTDYWFQKHQE 186
Consensus 219 DEksVDYYRKHWWRCCGPDCGNRikratkigPPYHGRVKRAAdaNRACGPNDFWWAWHQK 278
++ +++++++++++++++++++ +++++++++++ ++++++++++++++++
Consensus 219 DEksVDYYRKHWWRCCGPDCGNRikratkigPPYHGRVKRAAdaNRACGPNDFWWAWHQK 278
A0BYE9_PAR 140 DE..VDRCRNHIWRCNGR-CQQK........PPFFGYVKRAI..NRPPGKTDYWFQKHQE 186
A0BYE9_PAR 187 ECGG 190
Consensus 279 TCGG 282
++++
Consensus 279 TCGG 282
A0BYE9_PAR 187 ECGG 190
>Hit (#2): DUF335
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Download Putative metallopeptidase (SprT family) This family of uncharacterised proteins may be zinc
metallopeptidases.
Length=155
Score = 34.4, Expect = 9.7e-15
Match = 120/171 (70%), Insert = 0/171 (0%), Delete = 51/171 (30%)
Query 31 MMMMMMDMMMMMMMMMMMDMDDDDDDDDDDDMMMMMMMMMMMMMMMMMMMMMMMMMMMMM 90
Sbjct 22 MMMMMM~MMMMMMMMMMM~M~~~~~~~~~~~MMMMMMMMMMMMMMMMMMMMMMMMMMMMM 68
Query 91 MMMMMMDDMM~MMMDMMMMMMMMMMMMMMMMMDDDDDDDDDDDMMMMMMMMDDMMMMMM~ 148
Sbjct 69 MMMMMM~~MMDMMM~MMMMMMMMMMMMMMMMM~~~~~~~~~~~MMMMMMMM~~MMMMMMD 112
Query 149 ~MMMMMMMDDMMM~~~MMMMMMMMMMMM~~~MMMMMMDDDDDDDDDDDMMM 192
Sbjct 113 DMMMMMMM~~MMMDDDMMMMMMMMMMMMDDDMMMMMM~~~~~~~~~~~MMM 150
Aligned alignments:
A0BYE9_PAR 39 TVKW...ST-RMTLCAgkqfflskGTCKY.-E---..............--...--GQK. 67
Consensus 32 EVRWatdSKGRMTRTAgkqfflsiGICRYgAKREIiekkgpagtagscpAAshnRGGGGk 91
++++ ++ ++++++ +++++ +
Consensus 22 KANY:::NL~RGRTAG::::::::GAYLQ:~K~~~::::::::::::::~~:::~~~~~: 39
SPRT_ECOLI 37 KLSY:::TQ~RGTSAG::::::::TAWLE:~S~~~::::::::::::::~~:::~~~~~: 54
A0BYE9_PAR 68 -SC..............TIT..LSEPLLKFR..SNDELKS.................... 88
Consensus 92 KGCpeylpsqaayrhhaEIRieLSEPLLKLRnyPRKDLVEvssvdgralrtassflgssv 151
++ +++ +++++++++ +++++++
Consensus 40 ~NH::::::::::::::EIR::LNPKLLEEN::GEAFLEQ:::::::::::::::::::: 60
SPRT_ECOLI 55 ~Y-::::::::::::::EIR::LNPVLLLEN::SEAFIEE:::::::::::::::::::: 74
A0BYE9_PAR 89 ..TLLHEMIHAYLFITk...pSEAF~INE-.GHGPAFLEKMNFINQVT.--------GLE 131
Consensus 152 pqTLLHEMIHAYLFLIcgpagERLD~DRERdGHGPNFKKWMRRINKAQiKDHPRYPEGFN 210
++++++++++++++ ++ +++ +++++++++++++++++
Consensus 61 ::VVPHELAHLHLYQE:::::~~FGPRVK~:PHGAEWKLLMQQVFGLR:~~~~~~~~~~~ 97
SPRT_ECOLI 75 ::VVPHELAHLLVWKH:::::~~FG-RVA~:PHGKEWKWMMENVLGVP:~~~~~~~~~~~ 110
A0BYE9_PAR 132 LSVYHQFHDE..VDRCRN~~HIWRCNGR-CQQ~~~K........PPFFGYVKRAI..~NR 172
Consensus 211 ITVYHSFHDEksVDYYRK~~HWWRCCGPDCGN~~~RikratkigPPYHGRVKRAAda~NR 264
++++++++ ++++++ +++++++ +++ + +++++++++++ ++
Consensus 98 PCTCHQFA~~::VKSVKTKTYHYRCQC~~CGHNDFP::::::::LTRRRHNNVAKGEAEY 143
SPRT_ECOLI 111 ARRTHQFE~~::LQSVRRNTFPYRCKC~~QEH---Q::::::::LTVRRHNRVVRGEAVY 153
A0BYE9_PAR 173 PPGKTDYWFQKHQEECGG 190
Consensus 265 ACGPNDFWWAWHQKTCGG 282
++++ +++
Consensus 144 RCGK~~~~~~~~~~~CRG 150
SPRT_ECOLI 154 RCVH~~~~~~~~~~~CGE 160
>Hit (#3): Peptidase_M76
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Download Peptidase M76 family This is a family of metalloproteases. Proteins in this family
are also annotated as Ku70-binding proteins.
Length=181
Score = 15.1, Expect = 0.00013
Match = 26/28 (93%), Insert = 0/28 (0%), Delete = 2/28 (7%)
Query 65 MMMMMMMMMDDMMMMMMMMMMMMMMMMM 92
Sbjct 60 MMMMMMMMM~~MMMMMMMMMMMMMMMMM 85
Aligned alignments:
A0BYE9_PAR 71 IT..LSEPLL:::::::::::::::KFR..SNDELKS......................T 89
Consensus 110 IRieLSEPLL:::::::::::::::KLRnyPRKDLVEvssvdgralrtassflgssvpqT 154
++ ++++++ + +++++++ +
Consensus 121 IL::LCQNRIvldkatendsivpgaR~~::NKWHLED::::::::::::::::::::::T 152
Q4SST4_TET 93 IV::LCQNNI...............H~~::QQSHMNR::::::::::::::::::::::V 109
A0BYE9_PAR 90 LLHEMIHAY 98
Consensus 155 LLHEMIHAY 163
+++++++++
Consensus 153 LAHELVHAF 161
Q4SST4_TET 110 VTHELIHAF 118
>Hit (#4): WLM
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Download WLM domain This is a predicted metallopeptidase domain called WLM
(Wss1p-like metalloproteases). These are linked to the
Ub-system by virtue of fusions with the UB-binding PUG (PUB),
Ub-like, and Little Finger domains. More specifically, genetic
evidence implicates the WLM family in de-SUMOylation.
Length=252
Score = 12.4, Expect = 0.0033
Match = 40/47 (85%), Insert = 0/47 (0%), Delete = 7/47 (15%)
Query 46 MMMDMMMMDDDMMMMDMMMMMMMMMM~~MMMMMMMMMMMMMMMMMMM 90
Sbjct 62 MMM~MMMM~~~MMMM~MMMMMMMMMMDDMMMMMMMMMMMMMMMMMMM 103
Aligned alignments:
A0BYE9_PAR 61 CKY.-E---..............--...--GQK.-S::::::::::::::::::C..... 69
Consensus 58 CRYgAKREIiekkgpagtagscpAAshnRGGGGkKG::::::::::::::::::Cpeylp 99
+++ ++++ ++++ + +
Consensus 77 RLL:~GLNV::::::::::::::~~:::~NKGE:~KgmiwhvqavvvysltfqsI::::: 107
Q8IJV0_PLA 61 -LL:~GLNI::::::::::::::~~:::~VKKS:~E..................I::::: 72
A0BYE9_PAR 70 .........TIT..LSEPL~~LKFR..SNDELKS......................TLLH 92
Consensus 100 sqaayrhhaEIRieLSEPL~~LKLRnyPRKDLVEvssvdgralrtassflgssvpqTLLH 157
+++ +++++ ++++ +++++++ ++++
Consensus 108 :::::::::ELR::LRTDSDDKGFL::PYESIMG::::::::::::::::::::::TMLH 132
Q8IJV0_PLA 73 :::::::::KIR::LRKTKG-GEIF::HFNDIMG::::::::::::::::::::::TLLH 96
A0BYE9_PAR 93 EMIH 96
Consensus 158 EMIH 161
++++
Consensus 133 ELAH 136
Q8IJV0_PLA 97 ELVH 100
>Hit (#5): DUF2265
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Download Predicted aminopeptidase (DUF2265) Members of this family of bacterial proteins comprise various
hypothetical proteins and putative aminopeptidases. Their exact
function, has not, as yet, been defined.
Length=351
Score = 12.0, Expect = 0.0052
Match = 37/40 (92%), Insert = 0/40 (0%), Delete = 3/40 (8%)
Query 66 MMMMMMMMDDMMMMMMMMMMMMMMMMMMMMMMMMMMMMDM 105
Sbjct 159 MMMMMMMM~~MMMMMMMMMMMMMMMMMMMMMMMMMMMM~M 195
Aligned alignments:
A0BYE9_PAR 72 T..LSEPLL:KFR..SNDELKS......................TLLHEMIHAYLFITk. 103
Consensus 111 RieLSEPLL:KLRnyPRKDLVEvssvdgralrtassflgssvpqTLLHEMIHAYLFLIcg 169
+ ++++++ + +++++++ ++++++++++++++
Consensus 164 L::LNTFIRdW~~::PDGELAR::::::::::::::::::::::LIFHELAHQVVYVK:: 193
Q0VRR5_ALC 161 L::TTPMIQ.R~~::SKPSLAE::::::::::::::::::::::LLIHELAHRKLYIK:: 189
A0BYE9_PAR 104 ..pSEAFINE-.G 112
Consensus 170 pagERLDDRERdG 182
+++++++ +
Consensus 194 :::GDTAFNE~:S 201
Q0VRR5_ALC 190 :::GDTRFNE~:S 197
>Hit (#6): Peptidase_M48
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Download Peptidase family M48
Length=233
Score = 11.2, Expect = 0.015
Match = 28/31 (90%), Insert = 0/31 (0%), Delete = 3/31 (10%)
Query 65 MMMMMMMM~~MM~MMMMMMMMMMMMMMMMMM 92
Sbjct 41 MMMMMMMMDDMMDMMMMMMMMMMMMMMMMMM 71
Aligned alignments:
A0BYE9_PAR 71 IT..LSEPLL~~KF:::::::::::::::::::::::::::::::::::::~R..SNDEL 86
Consensus 110 IRieLSEPLL~~KL:::::::::::::::::::::::::::::::::::::~RnyPRKDL 129
++ ++++++ ++ + +++++
Consensus 42 VV::VTTGLLDKLAysvlnkdiqedsgmeprneeegnseeikakvknkkqgCL::TEDEL 97
O04602_ARA 182 IV::LYDTLI--QQ.....................................CK::NEDEI 198
A0BYE9_PAR 87 KS......................TLLHEMIHAY 98
Consensus 130 VEvssvdgralrtassflgssvpqTLLHEMIHAY 163
++ ++++++++++
Consensus 98 AAlrf:::::::::::::::::::VLGHEIGHIK 112
O04602_ARA 199 VA...:::::::::::::::::::VIAHELGHWK 210
>Hit (#7): BSP
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Download Plant Basic Secretory Protein These basic secretory proteins (BSPs) are believed to be part of
the plants defence mechanism against pathogens.
Length=249
Score = 10.8, Expect = 0.023
Match = 36/45 (80%), Insert = 0/45 (0%), Delete = 9/45 (20%)
Query 58 MMMDMMMMMMMMMMMMMMMM~~~~~~~~MMMMMMMMMMMMMMMMM 94
Sbjct 93 MMM~MMMMMMMMMMMMMMMMDDDDDDDDMMMMMMMMMMMMMMMMM 136
Aligned alignments:
A0BYE9_PAR 65 GQK.-SC..............TIT..LSEPLLKFR..SN~::::~~~~~~~:DELKS... 88
Consensus 88 GGGkKGCpeylpsqaayrhhaEIRieLSEPLLKLRnyPR~::::~~~~~~~:KDLVEvss 134
+++ ++ +++ +++++++++ ++ +++++
Consensus 148 DDD:~HN::::::::::::::EIH::LSARYVAGI::SAEvrkgPGDVKLAtAEVTG::: 184
Q9FWU3_ORY 125 ---:~-D::::::::::::::GIH::LSARYVGGY::SAA....-GDVR--.AEVTG::: 149
A0BYE9_PAR 89 ...................TLLHEMIHAYLF 100
Consensus 135 vdgralrtassflgssvpqTLLHEMIHAYLF 165
++++++++++++
Consensus 185 :::::::::::::::::::VLYHELVHVWQW 196
Q9FWU3_ORY 150 :::::::::::::::::::VLYHEATHVWQW 161
>Hit (#8): Peptidase_M56
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Download BlaR1 peptidase M56 Production of beta-Lactamase and penicillin-binding protein 2a
(which mediate staphylococcal resistance to beta-lactam
antibiotics) is regulated by a signal-transducing integral
membrane protein and a transcriptional repressor. The
signal transducer is a fusion protein with penicillin-binding
and zinc metalloprotease domains. The signal for protein
expression is transmitted by site-specific proteolytic cleavage
of both the transducer, which auto-activates, and the repressor,
which is inactivated, unblocking gene transcription. Homologues
to this peptidase domain, which corresponds to Merops family
M56, are also found in a number of other bacterial genome
sequences.
Length=97
Score = 10.0, Expect = 0.059
Match = 33/34 (97%), Insert = 0/34 (0%), Delete = 1/34 (3%)
Query 58 MMMDMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM 91
Sbjct 5 MMM~MMMMMMMMMMMMMMMMMMMMMMMMMMMMMM 37
Aligned alignments:
A0BYE9_PAR 65 GQK.-SC..............TIT..LSEPLLKFR..SNDELKS................ 88
Consensus 88 GGGkKGCpeylpsqaayrhhaEIRieLSEPLLKLRnyPRKDLVEvssvdgralrtassfl 147
+++ ++ +++ +++++++++ +++++++
Consensus 5 GLW:~KP::::::::::::::RIV::LPADFDTRY::SDEERDY:::::::::::::::: 28
Q9K4N2_STA 174 WYG:~KY::::::::::::::IIL::IPSSYFKSV::IDKRLKY:::::::::::::::: 197
A0BYE9_PAR 89 ......TLLHEMIHA 97
Consensus 148 gssvpqTLLHEMIHA 162
+++++++++
Consensus 29 ::::::ILAHELAHL 37
Q9K4N2_STA 198 ::::::IILHEYAHA 206
>Hit (#9): Mcm10
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Download Mcm10 replication factor Mcm10 is a eukaryotic DNA replication factor that regulates the
stability and chromatin association of DNA polymerase alpha.
Length=378
Score = 9.1, Expect = 0.19
Match = 46/52 (88%), Insert = 0/52 (0%), Delete = 6/52 (12%)
Query 133 MMMMMMMMDDMMMMMMMMMMMMMDDMMMMMMMMMMMMMMMMMMMMMDDMMMM 184
Sbjct 302 MMMMMMMM~~MMMMMMMMMMMMM~~MMMMMMMMMMMMMMMMMMMMM~~MMMM 347
Aligned alignments:
A0BYE9_PAR 132 LSVYHQFHDE..VDRCRNHIWRCNGR-CQQK........PPFFGYVKRAI..NRPPGKTD 178
Consensus 211 ITVYHSFHDEksVDYYRKHWWRCCGPDCGNRikratkigPPYHGRVKRAAdaNRACGPND 270
++++++++ +++++++++++++ ++++ +++++++++++ ++++++
Consensus 307 VEENHDLH~~::WHDAVKRFFKCPD~~CGNR::::::::TISLDRLPKKH::CSHCGL~~ 348
MCM10_DANR 756 VEEKHDYH~~::WHDAVKRFFKCP-~~CGQR::::::::KICLARMPHGA::CSHCGL~~ 796
A0BYE9_PAR 179 YWFQ 182
Consensus 271 FWWA 274
++++
Consensus 349 FKWE 352
MCM10_DANR 797 FKWE 800
>Hit (#10): Peptidase_M30
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Download Peptidase M30 This family contains the metallopeptidase hyicolysin.
Hyicolysin has a zinc ion which is liganded by two histidine and
one glutamate residue.
Length=419
Score = 8.1, Expect = 0.62
Match = 40/43 (93%), Insert = 0/43 (0%), Delete = 3/43 (7%)
Query 78 MMMMMMMMMMMMMMMMMMMDDMMMMMDMMMMMMMMMMMMMMMM 120
Sbjct 152 MMMMMMMMMMMMMMMMMMM~~MMMMM~MMMMMMMMMMMMMMMM 191
Aligned alignments:
A0BYE9_PAR 84 DELKS......................TLLHEMIHAYLFITk...pSEAFINE-.GHGPA 116
Consensus 127 KDLVEvssvdgralrtassflgssvpqTLLHEMIHAYLFLIcgpagERLDDRERdGHGPN 186
+++++ ++++++++++++++ +++++ +++++
Consensus 152 NQVLS::::::::::::::::::::::TMAHEFMHMQNFYR:::::~~RGVLM~:GAQYA 180
A0G8I2_9BU 345 NQMLT::::::::::::::::::::::TMAHESMHMQNFYR:::::~~RSVQM~:GAQYA 373
A0BYE9_PAR 117 FLEKMNFINQV 127
Consensus 187 FKKWMRRINKA 197
+++++++++++
Consensus 181 FDTWLEEMTAM 191
A0G8I2_9BU 374 FEPWLEEMTAM 384
>Hit (#11): PipA
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Download PipA protein This family consists of several Salmonella PipA (pathogenicity
island-encoded protein A) and related phage sequences. PipA is
thought to contribute to enteric but not to systemic
salmonellosis.
Length=228
Score = 7.7, Expect = 0.97
Match = 29/31 (94%), Insert = 0/31 (0%), Delete = 2/31 (6%)
Query 79 MMMMMMMMMMMMMMMMMMDMMMMMMDMMMMM 109
Sbjct 175 MMMMMMMMMMMMMMMMMM~MMMMMM~MMMMM 203
Aligned alignments:
A0BYE9_PAR 85 ELKS......................TLLHEMIHAYLFITk...pSEAFINE-.GHGPA 116
Consensus 128 DLVEvssvdgralrtassflgssvpqTLLHEMIHAYLFLIcgpagERLDDRERdGHGPN 186
++++ ++++++++++++++ ++++++ +++++
Consensus 175 DTKR::::::::::::::::::::::SFIHEVVHALTHLQ:::::~DKEDNH~:PRGPV 203
Q9MBM0_9VI 175 DTTR::::::::::::::::::::::SFIHEVVHALTHLQ:::::~DKEDSN~:PRGPV 203