#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6DDZ8	uniprotkb:O14640	intact:EBI-3511416	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:q6ddz8_xenla(display_long)|uniprotkb:mink(gene name synonym)|uniprotkb:mink1(gene name)|psi-mi:mink1(display_short)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lee et al. (2007)	pubmed:17627283|imex:IM-14004|mint:MINT-5220095	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7499362|imex:IM-14004-10|mint:MINT-5224924	intact-miscore:0.40	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002290(Serine/threonine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR001180(Citron-like)|go:"GO:0005083"(small GTPase regulator activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|refseq:NP_001086720.1|mint:MINT-5224929(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-5224926(identity)	-	-	-	figure legend:f7a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/24	2013/09/06	rogid:XzWD3WpMafUtWq7DQ+8If2aZ6z08355	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:9AACBD93EBF37654|rigid:HVLAQTQ7LIY8jWbeITa50XxOTv4	false	myc tag:?-?(MINT-5224930)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25788	uniprotkb:O14640	intact:EBI-348380|uniprotkb:B2RCK6|uniprotkb:Q9BS70|uniprotkb:Q8N1D8|uniprotkb:Q86U83	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:psa3_human(display_long)|uniprotkb:PSMA3(gene name)|psi-mi:PSMA3(display_short)|uniprotkb:PSC8(gene name synonym)|uniprotkb:Proteasome component C8(gene name synonym)|uniprotkb:Macropain subunit C8(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C8(gene name synonym)|uniprotkb:HC8(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wang et al. (2011)	imex:IM-15364|pubmed:21988832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3928847|imex:IM-15364-2091	intact-miscore:0.44	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|go:"GO:0016032"(viral process)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0051437"(positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)|go:"GO:0051436"(negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006915"(apoptotic process)|go:"GO:0031145"(anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0044281"(small molecule metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0005839"(proteasome core complex)|go:"GO:0019048"(modulation by virus of host morphology or physiology)|ensembl:ENSG00000100567|refseq:NP_687033.1|refseq:NP_002779.1|reactome:REACT_6900|reactome:REACT_383|reactome:REACT_13505|reactome:REACT_6850|reactome:REACT_578|reactome:REACT_21300|reactome:REACT_71|reactome:REACT_21257|reactome:REACT_116125|reactome:REACT_115566|reactome:REACT_111217|reactome:REACT_111102|ipi:IPI00419249|ipi:IPI00171199|entrezgene/locuslink:5684(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|entrezgene/locuslink:1855(identity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/05/18	2011/05/18	rogid:9Er/PY50/GVoCr5yAPXlkfxtP0k9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:B0CB60B37993EBEE|rigid:wF2CYXAZZTa1aRucjncaQQ6+i50	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96FS4	uniprotkb:O14640	intact:EBI-1054981|uniprotkb:O60618|uniprotkb:O60484|uniprotkb:O14518|uniprotkb:Q2YD83	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:sipa1_human(display_long)|uniprotkb:GTPase-activating protein Spa-1(gene name synonym)|uniprotkb:p130 SPA-1(gene name synonym)|uniprotkb:SIPA1(gene name)|psi-mi:SIPA1(display_short)|uniprotkb:SPA1(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wang et al. (2011)	imex:IM-15364|pubmed:21988832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3928857|imex:IM-15364-2092	intact-miscore:0.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000331(Rap/ran-GAP)|interpro:IPR001478(PDZ/DHR/GLGF)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008283"(cell proliferation)|go:"GO:0046582"(Rap GTPase activator activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000213445|ensembl:ENSG00000213445|refseq:XP_005274246.1|refseq:NP_694985.29|refseq:NP_006738.3|reactome:REACT_6900|ipi:IPI00305305|entrezgene/locuslink:6494(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|entrezgene/locuslink:1855(identity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table S2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/05/18	2011/05/18	rogid:N5g/PMrgPEjYn5Cqv5uo0cAMPJI9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:A362523DE5117A86|rigid:o+IwnOIkF1nf9qCBnTMYaP9yGN4	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y4D1	uniprotkb:O14640	intact:EBI-2817289|uniprotkb:Q8TB39|uniprotkb:Q86U34|uniprotkb:Q8N1Z8	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:daam1_human(display_long)|uniprotkb:DAAM1(gene name)|psi-mi:DAAM1(display_short)|uniprotkb:KIAA0666(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Steele et al. (2012)	pubmed:22705156|mint:MINT-8379817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7930480|mint:MINT-8379825	intact-miscore:0.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR027650|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR011989(Armadillo-like helical)|rcsb pdb:2Z6E|rcsb pdb:2J1D|go:"GO:0001725"(stress fiber)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000100592|ensembl:ENSG00000100592|refseq:XP_005267488.1|refseq:XP_005267487.1|refseq:NP_001257449.1|refseq:NP_055807.1|ipi:IPI00337802|ipi:IPI00337801|ipi:IPI00337800|mint:MINT-8379828(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-8379827(identity)	-	-	-	figure legend:f3b|comment:homomint|comment:mint	taxid:9606(human-platelets)|taxid:9606(Homo sapiens platelets, thrombocytes)	-	2012/05/23	2013/08/22	rogid:nAvD3Yprt2Ayj2wLfyI15HIoyLI9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:BDCD60FC9E357647|rigid:KCoeOZ6iPi5IcW+H8gAPfeIivgk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20073	uniprotkb:O14640	intact:EBI-2338704|uniprotkb:Q5T0M7|uniprotkb:Q5T0M6|uniprotkb:Q5F2H3	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:anxa7_human(display_long)|uniprotkb:ANXA7(gene name)|psi-mi:ANXA7(display_short)|uniprotkb:ANX7(gene name synonym)|uniprotkb:SNX(gene name synonym)|uniprotkb:Annexin-7(gene name synonym)|uniprotkb:Annexin VII(gene name synonym)|uniprotkb:Synexin(gene name synonym)|uniprotkb:OK/SW-cl.95(orf name)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Vinayagam et al. (2011)	pubmed:21900206|imex:IM-16799|mint:MINT-8089645|doi:10.1126/scisignal.2001699	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7097611|imex:IM-16799-58|mint:MINT-8248285	intact-miscore:0.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013286(Annexin, type VII)|interpro:IPR018252|interpro:IPR018502|interpro:IPR001464(Annexin)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0031982"(vesicle)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0009651"(response to salt stress)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008283"(cell proliferation)|go:"GO:0007599"(hemostasis)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005635"(nuclear envelope)|go:"GO:0035176"(social behavior)|ensembl:ENSG00000138279|refseq:NP_004025.1|refseq:NP_001147.1|ipi:IPI00021771|ipi:IPI00002460|mint:MINT-8248286(identity)|uniprotkb:P20073(original identifier)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-8248291(identity)|uniprotkb:O14640(original identifier)	-	-	-	figure legend:SF2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292("Saccharomyces cerevisiae (strain ATCC 204508 / S288c)")	-	2011/10/20	2013/08/21	rogid:ad3I49rhRoZ0hG8ruDgSQWocVuw9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:0F5B5211E8DA4BF0|rigid:So1nY0EaCIs972IS053gotFPf8c	false	fusion protein:?-?(MINT-8248289)	fusion protein:?-?(MINT-8248294)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8IW93	uniprotkb:O14640	intact:EBI-7799822|intact:MINT-6504085|uniprotkb:A6NJ04|uniprotkb:Q5TEV2|uniprotkb:Q6PJQ4|uniprotkb:Q8N244	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:arhgj_human(display_long)|uniprotkb:Ephexin-2(gene name synonym)|uniprotkb:ARHGEF19(gene name)|psi-mi:ARHGEF19(display_short)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tanegashima et al. (2008)	pubmed:18256687|imex:IM-13972|mint:MINT-6493368	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7800269|imex:IM-13972-1|mint:MINT-6504080	intact-miscore:0.40	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0042060"(wound healing)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0005089"(Rho guanyl-nucleotide exchange factor activity)|go:"GO:0032321"(positive regulation of Rho GTPase activity)|ensembl:ENSG00000142632|refseq:NP_694945.2|ipi:IPI00642092|ipi:IPI00217197|mint:MINT-6504082(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-6504083(identity)	-	comment:mint	-	figure legend:F5C F5E F6B|comment:Interaction is abolished when N-Daam1 is also overexpressed.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/04/08	2013/08/22	rogid:XVGLoKdF1sPt0ldRsV1otDW/2Iw9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:74C8ED80CF90ECE3|rigid:ZRKb4/uCBi9vmjzDZ6spUS6HIwE	false	binding-associated region:1-212(MINT-6504332)|flag tag:?-?(MINT-6504154)	myc tag:?-?(MINT-6504158)|binding-associated region:134-432(MINT-6504328)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P25054	uniprotkb:O14640	intact:EBI-727707|uniprotkb:Q93042|uniprotkb:Q15163|uniprotkb:Q15162|uniprotkb:D3DT03	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Matsumoto et al. (2010)	pubmed:20224554|imex:IM-15079|mint:MINT-7890890|doi:10.1038/emboj.2010.26	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7848652|imex:IM-15079-2|mint:MINT-7897055	intact-miscore:0.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR026836|interpro:IPR026831|interpro:IPR026818|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR009223(APC cysteine-rich)|rcsb pdb:3QHE|rcsb pdb:3AU3|rcsb pdb:4G69|rcsb pdb:3T7U|rcsb pdb:3RL8|rcsb pdb:3RL7|rcsb pdb:3NMZ|rcsb pdb:3NMX|rcsb pdb:3NMW|rcsb pdb:2RQU|rcsb pdb:1V18|rcsb pdb:1TH1|rcsb pdb:1T08|rcsb pdb:1M5I|rcsb pdb:1JPP|rcsb pdb:1EMU|rcsb pdb:1DEB|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051276"(chromosome organization)|go:"GO:0051171"(regulation of nitrogen compound metabolic process)|go:"GO:0048538"(thymus development)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0044295"(axonal growth cone)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0042483"(negative regulation of odontogenesis)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0035019"(somatic stem cell maintenance)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009798"(axis specification)|go:"GO:0008285"(negative regulation of cell proliferation)|go:"GO:0007409"(axonogenesis)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0001942"(hair follicle development)|go:"GO:0001822"(kidney development)|go:"GO:0070830"(tight junction assembly)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0006461"(protein complex assembly)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0007094"(mitotic spindle assembly checkpoint)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0006921"(cellular component disassembly involved in execution phase of apoptosis)|go:"GO:0016477"(cell migration)|go:"GO:0007050"(cell cycle arrest)|go:"GO:0007155"(cell adhesion)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0005923"(tight junction)|go:"GO:0032587"(ruffle membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0000776"(kinetochore)|go:"GO:0005829"(cytosol)|go:"GO:0005813"(centrosome)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0005912"(adherens junction)|ensembl:ENSG00000134982|ensembl:ENSG00000134982|ensembl:ENSG00000134982|refseq:NP_001120982.1|refseq:NP_000029.2|refseq:XP_005272034.1|refseq:XP_005272032.1|refseq:XP_005272031.1|reactome:REACT_111102|reactome:REACT_578|ipi:IPI00215877|ipi:IPI00012391|mint:MINT-7897059(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-7897057(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:fs16b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/05/04	2013/08/22	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:E97DCF3B6BF75F13|rigid:XKSwpCq4J25RCTrXjVDP06Kdrk4	false	-	ha tag:?-?(MINT-7897064)|binding-associated region:337-670(MINT-7897067)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14640	uniprotkb:O14641	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	intact:EBI-740850|uniprotkb:Q53XM0|uniprotkb:D3DTN3	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Matsumoto et al. (2010)	pubmed:20224554|imex:IM-15079|mint:MINT-7890890|doi:10.1038/emboj.2010.26	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7848586|imex:IM-15079-1|mint:MINT-7897032	intact-miscore:0.35	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-7897043(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|rcsb pdb:3CC0|rcsb pdb:3CBZ|rcsb pdb:3CBY|rcsb pdb:3CBX|rcsb pdb:2REY|go:"GO:0060026"(convergent extension)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0007379"(segment specification)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of sequence-specific DNA binding transcription factor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0001843"(neural tube closure)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0021535"(cell migration in hindbrain)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0004871"(signal transducer activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0045177"(apical part of cell)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0035329"(hippo signaling)|go:"GO:0003151"(outflow tract morphogenesis)|ensembl:ENSG00000004975|refseq:NP_004413.1|reactome:REACT_111102|ipi:IPI00023103|mint:MINT-7897036(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:fs16a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/05/04	2013/08/22	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	intact-crc:2CA753F318299BB0|rigid:yF3vu7Bzw7lF2atNaZkPsJJsDoo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14640	uniprotkb:Q05397	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	intact:EBI-702142|uniprotkb:Q9UD85|uniprotkb:Q14291|uniprotkb:F5H4S4|uniprotkb:B4E2N6	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:fak1_human(display_long)|uniprotkb:PTK2(gene name)|psi-mi:PTK2(display_short)|uniprotkb:FAK(gene name synonym)|uniprotkb:FAK1(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 71(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Matsumoto et al. (2010)	pubmed:20224554|imex:IM-15079|mint:MINT-7890890|doi:10.1038/emboj.2010.26	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7848672|imex:IM-15079-3|mint:MINT-7897075	intact-miscore:0.35	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-7897086(identity)	interpro:IPR020635|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR019748|interpro:IPR019749|rcsb pdb:4I4E|rcsb pdb:3BZ3|rcsb pdb:3B71|rcsb pdb:2RA7|rcsb pdb:2IJM|rcsb pdb:2ETM|rcsb pdb:1OW8|rcsb pdb:1OW7|rcsb pdb:1OW6|rcsb pdb:1MP8|rcsb pdb:1K05|rcsb pdb:1K04|rcsb pdb:4I4F|rcsb pdb:4EBW|rcsb pdb:3S9O|rcsb pdb:4EBV|rcsb pdb:4KAO|rcsb pdb:4KAB|rcsb pdb:4K9Y|rcsb pdb:4K8A|rcsb pdb:4GU9|rcsb pdb:4GU6|rcsb pdb:3PXK|go:"GO:0007172"(signal complex assembly)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0006921"(cellular component disassembly involved in execution phase of apoptosis)|go:"GO:0007411"(axon guidance)|go:"GO:0004871"(signal transducer activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0005829"(cytosol)|go:"GO:0045087"(innate immune response)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0045909"(positive regulation of vasodilation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0042493"(response to drug)|go:"GO:0042383"(sarcolemma)|go:"GO:0032355"(response to estradiol)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0016604"(nuclear body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0009749"(response to glucose)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0007254"(JNK cascade)|go:"GO:0005730"(nucleolus)|go:"GO:0003779"(actin binding)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0040023"(establishment of nucleus localization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001570"(vasculogenesis)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005856"(cytoskeleton)|go:"GO:0048870"(cell motility)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0038007"(netrin-activated signaling pathway)|go:"GO:0032319"(regulation of Rho GTPase activity)|go:"GO:0030168"(platelet activation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0009790"(embryo development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0001890"(placenta development)|go:"GO:0001525"(angiogenesis)|go:"GO:2000060"(positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008284"(positive regulation of cell proliferation)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000169398|ensembl:ENSG00000169398|refseq:NP_722560.1|refseq:NP_001186578.1|reactome:REACT_604|reactome:REACT_578|reactome:REACT_6900|reactome:REACT_111155|reactome:REACT_111102|reactome:REACT_111045|ipi:IPI01011193|ipi:IPI00982478|ipi:IPI00216218|ipi:IPI00216217|ipi:IPI00973349|mint:MINT-7897091(identity)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:fs16c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/05/04	2013/08/22	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:8q4JfaNYtMdXVLU77d1EtSP0lVg9606	intact-crc:4568CD0D83A3C52E|rigid:BkQeEobJp5fOwApi9JxBVLeqjas	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92995	uniprotkb:O14640	intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:B4DYF3|uniprotkb:A8K2S3|uniprotkb:Q96B25	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0398"(two hybrid pooling approach)	Stelzl et al. (2005)	pubmed:16169070|imex:IM-16517|mint:MINT-5217955	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-736160|imex:IM-16517-2558	author score:SD4|intact-miscore:0.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR000449(Ubiquitin-associated/translation elongation factor EF1B, N-terminal)|interpro:IPR009060(UBA-like)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|rcsb pdb:2LBC|rcsb pdb:2L80|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0004843"(ubiquitin-specific protease activity)|go:"GO:0004221"(ubiquitin thiolesterase activity)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0050821"(protein stabilization)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0008283"(cell proliferation)|go:"GO:0006914"(autophagy)|go:"GO:0006355"(regulation of transcription, DNA-templated)|ensembl:ENSG00000058056|refseq:NP_003931.2|ipi:IPI00024401|ipi:IPI00947195	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	psi-mi:"MI:0469"(intact)	-	-	dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/10/19	2008/09/22	rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:1AFA84C7A7DD7BF9|rigid:p+ve4FzWLfa4eTs9wUJpLk5CGTo	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14186	uniprotkb:O14640	intact:EBI-749713|uniprotkb:Q5JSB4|uniprotkb:Q8IZL5	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:tfdp1_human(display_long)|uniprotkb:E2F dimerization partner 1(gene name synonym)|uniprotkb:DRTF1-polypeptide 1(gene name synonym)|uniprotkb:TFDP1(gene name)|psi-mi:TFDP1(display_short)|uniprotkb:DP1(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2012)	doi:10.1038/emboj.2012.181|pubmed:22773187|imex:IM-18767|mint:MINT-8403810	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963686|imex:IM-18767-10|mint:MINT-8404100	intact-miscore:0.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR028313|interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR015648(Transcription factor DP)|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|rcsb pdb:2AZE|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0008283"(cell proliferation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005667"(transcription factor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|ensembl:ENSG00000198176|refseq:NP_009042.1|refseq:XP_005268384.1|refseq:XP_005268383.1|reactome:REACT_115566|reactome:REACT_578|reactome:REACT_120956|reactome:REACT_116125|reactome:REACT_71|reactome:REACT_111102|ipi:IPI00029095|mint:MINT-8404107(identity)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-8404103(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/12/07	2013/08/22	rogid:FvCKBqPptRL9BKBmt+F9kA7oU8k9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:346D40F01203B96C|rigid:G3arliPGlw33tx261AbHO0gvvU4	false	-	ha tag:?-?(MINT-8404104)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14640	uniprotkb:Q14186	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	intact:EBI-749713|uniprotkb:Q5JSB4|uniprotkb:Q8IZL5	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:tfdp1_human(display_long)|uniprotkb:E2F dimerization partner 1(gene name synonym)|uniprotkb:DRTF1-polypeptide 1(gene name synonym)|uniprotkb:TFDP1(gene name)|psi-mi:TFDP1(display_short)|uniprotkb:DP1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2012)	doi:10.1038/emboj.2012.181|pubmed:22773187|imex:IM-18767|mint:MINT-8403810	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7963754|imex:IM-18767-11|mint:MINT-8404114	intact-miscore:0.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100|mint:MINT-8404118(identity)	interpro:IPR028313|interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR015648(Transcription factor DP)|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|rcsb pdb:2AZE|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0008283"(cell proliferation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003700"(sequence-specific DNA binding transcription factor activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005667"(transcription factor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0045944"(positive regulation of transcription from RNA polymerase II promoter)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|ensembl:ENSG00000198176|refseq:NP_009042.1|refseq:XP_005268384.1|refseq:XP_005268383.1|reactome:REACT_115566|reactome:REACT_578|reactome:REACT_120956|reactome:REACT_116125|reactome:REACT_71|reactome:REACT_111102|ipi:IPI00029095|mint:MINT-8404116(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf3a sf3b sf3d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/12/07	2013/08/22	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:FvCKBqPptRL9BKBmt+F9kA7oU8k9606	intact-crc:6E73F0C2713BEB63|rigid:G3arliPGlw33tx261AbHO0gvvU4	false	binding-associated region:475-670(MINT-8404124)|ha tag:?-?(MINT-8404119)	green fluorescent protein tag:?-?(MINT-8404127)|binding-associated region:1-112,197-268(MINT-8404129)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98078	uniprotkb:O14640	intact:EBI-1391846|uniprotkb:Q923E1|uniprotkb:Q91W56|uniprotkb:Q3U3K1	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:dab2_mouse(display_long)|uniprotkb:DOC-2(gene name synonym)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hocevar et al. (2003)	pubmed:12805222|imex:IM-21820	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6306107|imex:IM-21820-3	intact-miscore:0.40	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1P3R|rcsb pdb:1M7E|go:"GO:0005737"(cytoplasm)|go:"GO:0006907"(pinocytosis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0007588"(excretion)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0005634"(nucleus)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0007492"(endoderm development)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:0070022"(transforming growth factor beta receptor homodimeric complex)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060391"(positive regulation of SMAD protein import into nucleus)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0015031"(protein transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0005178"(integrin binding)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2000370"(positive regulation of clathrin-mediated endocytosis)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0007257"(activation of JUN kinase activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032091"(negative regulation of protein binding)|ensembl:ENSMUSG00000022150|refseq:NP_075607.2|refseq:NP_001032994.1|refseq:NP_001008702.1|ipi:IPI00308852|ipi:IPI00222828|ipi:IPI00222829	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	-	-	-	figure legend:1E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/24	2012/09/24	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:420757B7DEFE728B|rigid:BcZBBjwKvhL9IrLW3Wmzf2qpce8	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O75901	uniprotkb:O14640	intact:EBI-6871931|uniprotkb:Q8N5U8|uniprotkb:B3KMQ4	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:rasf9_human(display_long)|uniprotkb:Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor(gene name synonym)|uniprotkb:PAM COOH-terminal interactor protein 1(gene name synonym)|uniprotkb:PAMCI(gene name synonym)|uniprotkb:PCIP1(gene name synonym)|uniprotkb:RASSF9(gene name)|psi-mi:RASSF9(display_short)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hauri et al. (2013)	imex:IM-20985|pubmed:24366813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6912184|imex:IM-20985-26	intact-miscore:0.35	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000159(Ras-association)|go:"GO:0016197"(endosomal transport)|go:"GO:0012510"(trans-Golgi network transport vesicle membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0006605"(protein targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005768"(endosome)|go:"GO:0005215"(transporter activity)|ensembl:ENSG00000198774|refseq:NP_005438.2|ipi:IPI00023105	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/07/31	2013/07/31	rogid:HCiQwhTEZsZcq7j67HiR5lZhV7c9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:DC4555E84681D47C|rigid:UPSpx0n4PuAZBnrLgpH3dwDQfpY	false	tandem tag:n-n("MI:0677")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:A6NK89	uniprotkb:O14640	intact:EBI-6912267	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:rasfa_human(display_long)|uniprotkb:RASSF10(gene name)|psi-mi:RASSF10(display_short)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hauri et al. (2013)	imex:IM-20985|pubmed:24366813	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6912271|imex:IM-20985-27	intact-miscore:0.35	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000159(Ras-association)|go:"GO:0007165"(signal transduction)|go:"GO:0005829"(cytosol)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0000922"(spindle pole)|refseq:NP_001073990.2|ipi:IPI00049961	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/07/31	2013/07/31	rogid:oyCU3b8EYEcm3ETjZj4/iMlxYGc9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:A232CE84D877279F|rigid:UHB5AhpVXhgCYep9KZzMmRoAke4	false	tandem tag:n-n("MI:0677")	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:O70239	uniprotkb:O14640	intact:EBI-6857773	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kishida et al. (1999)	pubmed:10330181	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	unknown:bhf-ucl(bhf-ucl)	intact:EBI-8761560	intact-miscore:0.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR000342(Regulator of G protein signalling)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|rcsb pdb:2D5G|rcsb pdb:1WSP|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0021881"(Wnt-activated signaling pathway involved in forebrain neuron fate commitment)|go:"GO:0038032"(termination of G-protein coupled receptor signaling pathway)|go:"GO:0035412"(regulation of catenin import into nucleus)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051443"(positive regulation of ubiquitin-protein ligase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:2000060"(positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0001743"(optic placode formation)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0055001"(muscle cell development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043623"(cellular protein complex assembly)|go:"GO:0008219"(cell death)|go:"GO:0060823"(canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(activation of JUN kinase activity)|go:"GO:0004871"(signal transducer activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0016023"(cytoplasmic membrane-bounded vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030877"(beta-catenin destruction complex)|ensembl:ENSRNOG00000020414|rgd:620859|refseq:NP_077381.1|ipi:IPI00231576	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	-	-	-	figure legend:Fig. 5C|dataset:Cardiac - Interactions involving cardiac related proteins|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/13	2013/09/13	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:7ACF5B9C7C45F63C|rigid:+uXwWOY8VkJAUnAnplk8uJwjVaQ	false	maltose binding protein tag:?-?|sufficient binding region:508-712	glutathione s tranferase tag:?-?|sufficient binding region:1-282	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14640	uniprotkb:Q92997	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	intact:EBI-739789|uniprotkb:Q92607|uniprotkb:Q8N5E9|uniprotkb:Q13531|uniprotkb:O14642|uniprotkb:B4E3E5|uniprotkb:D3DNT0	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kishida et al. (1999)	pubmed:10330181	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	unknown:bhf-ucl(bhf-ucl)	intact:EBI-8786179	intact-miscore:0.63	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0060026"(convergent extension)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0004871"(signal transducer activity)|go:"GO:0005938"(cell cortex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042493"(response to drug)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0007275"(multicellular organismal development)|go:"GO:0005622"(intracellular)|ensembl:ENSG00000161202|refseq:NP_004414.3|refseq:XP_005247230.1|ipi:IPI00643141|ipi:IPI00924552	-	-	-	figure legend:Fig. 2B|dataset:Cardiac - Interactions involving cardiac related proteins|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/13	2013/10/02	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606	intact-crc:D41FD77848C12244|rigid:N7f5wQIsQT32KqMrNK2QGqHb0BI	false	glutathione s tranferase tag:?-?|necessary binding region:1-82..82(IPR001158)	maltose binding protein tag:?-?|sufficient binding region:1-80(IPR001158)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92997	uniprotkb:O14640	intact:EBI-739789|uniprotkb:Q92607|uniprotkb:Q8N5E9|uniprotkb:Q13531|uniprotkb:O14642|uniprotkb:B4E3E5|uniprotkb:D3DNT0	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kishida et al. (1999)	pubmed:10330181	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	unknown:bhf-ucl(bhf-ucl)	intact:EBI-8761232	intact-miscore:0.63	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0060026"(convergent extension)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0004871"(signal transducer activity)|go:"GO:0005938"(cell cortex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042493"(response to drug)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0007275"(multicellular organismal development)|go:"GO:0005622"(intracellular)|ensembl:ENSG00000161202|refseq:NP_004414.3|refseq:XP_005247230.1|ipi:IPI00643141|ipi:IPI00924552	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	-	-	-	figure legend:Fig. 3B|dataset:Cardiac - Interactions involving cardiac related proteins|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/13	2013/10/02	rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:D41C61FB55F12244|rigid:N7f5wQIsQT32KqMrNK2QGqHb0BI	false	sufficient binding region:1-80(IPR001158)|maltose binding protein tag:?-?	glutathione s tranferase tag:?-?|necessary binding region:1-82(IPR001158)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14640	uniprotkb:O70239	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	intact:EBI-6857773	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kishida et al. (1999)	pubmed:10330181	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	unknown:bhf-ucl(bhf-ucl)	intact:EBI-8761543	intact-miscore:0.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR000342(Regulator of G protein signalling)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|rcsb pdb:2D5G|rcsb pdb:1WSP|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0021881"(Wnt-activated signaling pathway involved in forebrain neuron fate commitment)|go:"GO:0038032"(termination of G-protein coupled receptor signaling pathway)|go:"GO:0035412"(regulation of catenin import into nucleus)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051443"(positive regulation of ubiquitin-protein ligase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:2000060"(positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0001743"(optic placode formation)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0055001"(muscle cell development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043623"(cellular protein complex assembly)|go:"GO:0008219"(cell death)|go:"GO:0060823"(canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(activation of JUN kinase activity)|go:"GO:0004871"(signal transducer activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0016023"(cytoplasmic membrane-bounded vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030877"(beta-catenin destruction complex)|ensembl:ENSRNOG00000020414|rgd:620859|refseq:NP_077381.1|ipi:IPI00231576	-	-	-	figure legend:Fig. 5C|dataset:Cardiac - Interactions involving cardiac related proteins|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/13	2013/09/13	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:AF398CC0CBBA476D|rigid:+uXwWOY8VkJAUnAnplk8uJwjVaQ	false	sufficient binding region:281-670|glutathione s tranferase tag:?-?|sufficient binding region:1-282	maltose binding protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14640	uniprotkb:P49674	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	intact:EBI-749343	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857746|imex:IM-21248-1	intact-miscore:0.64	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:4HOK|rcsb pdb:4HNI|go:"GO:0007165"(signal transduction)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0006281"(DNA repair)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0030529"(ribonucleoprotein complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|refseq:NP_689407.1|refseq:NP_001885.1|reactome:REACT_24941|reactome:REACT_115566|ipi:IPI00027729	-	-	-	figure legend:Fig. 4a, Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2013/06/12	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:2D8EC8737F232821|rigid:WMxantXeSaraUl2rqExj20JkE0s	false	necessary binding region:336-519|ha tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	uniprotkb:O14640	intact:EBI-749343	intact:EBI-723489|uniprotkb:Q5TA35|uniprotkb:Q5TA33	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877795|imex:IM-21248-15	intact-miscore:0.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|rcsb pdb:4HOK|rcsb pdb:4HNI|go:"GO:0007165"(signal transduction)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0006281"(DNA repair)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0030529"(ribonucleoprotein complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0034613"(cellular protein localization)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|ensembl:ENSG00000213923|refseq:NP_689407.1|refseq:NP_001885.1|reactome:REACT_24941|reactome:REACT_115566|ipi:IPI00027729	interpro:IPR011991(Winged helix repressor DNA-binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR001158(DIX)|interpro:IPR003351(Dishevelled protein)|interpro:IPR024580|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|go:"GO:0006366"(transcription from RNA polymerase II promoter)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0021915"(neural tube development)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048668"(collateral sprouting)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0048675"(axon extension)|go:"GO:0004871"(signal transducer activity)|go:"GO:0045202"(synapse)|go:"GO:0005886"(plasma membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005874"(microtubule)|go:"GO:0030426"(growth cone)|go:"GO:0030425"(dendrite)|go:"GO:0005829"(cytosol)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0005938"(cell cortex)|go:"GO:0030424"(axon)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0048365"(Rac GTPase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035176"(social behavior)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0060026"(convergent extension)|ensembl:ENSG00000107404|refseq:NP_004412.2|refseq:XP_005244788.1|ipi:IPI00643229|ipi:IPI00023100	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2013/07/02	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:5638742C5BD0E7B0	false	enhanced green fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)